The peacekeepers, known as the C.O.W.-Boys, are led by a trio of deputies:

The story is set in the 19th-century American Southwest after a radioactive strikes Earth. The impact creates a massive, cloud-shrouded mesa and "cow-metizes" the local animals into "bovipomorphic" hybrids.

: These intelligent animals established Cowtown , a civilization mirroring the Wild West but with gaps in cultural knowledge they had to "fill in the blanks" for.

: The series blends traditional Western tropes with steampunk and supernatural "Weird West" elements. Primary Characters

: The acronym stands for the moral code the heroes live by.