[s4e16] House's Head (part 2) May 2026

: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship.

: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend. [S4E16] House's Head (Part 2)

: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control. : The finale fundamentally alters the series' core

The finale begins with House suffering from retrograde amnesia following a bus accident. Convinced he witnessed a life-threatening symptom in a fellow passenger before the crash, House undergoes increasingly dangerous procedures—including hypnosis and deep brain stimulation—to retrieve the lost memory. He eventually realizes her necklace is made of

For more detailed production history and award information, you can visit the House's Head Wikipedia page and the Wilson's Heart Wikipedia page .

In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure.