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Hawaii.five-0.2010.s09e21.web.x264-tbs[eztv].mkv

: The team investigates the murder of Dale Samson, an unlicensed private investigator. The investigation reveals that Samson was searching for a girl, Jennifer Nettles, who was kidnapped 20 years prior.

: Five-0 discovers that Jennifer is living under the name Emily Henderson with her kidnapper, Wade Henderson (real name Jesse Stoltz), who raised her as his own daughter after his own family died in a car accident.

: The episode features a recurring fan-favorite element involving Ricky Schiff and a cat named Mr. Pickles , who was bequeathed to Steve, Danny, and Ricky by a deceased neighbor. The cat eventually moves into McGarrett's house, leading to a "silent standoff" with Steve’s dog, Eddie. Cast : Alex O’Loughlin as Steve McGarrett. Scott Caan as Danny "Danno" Williams. Chi McBride as Lou Grover. Jorge Garcia as Jerry Ortega. Meaghan Rath as Tani Rey. Beulah Koale as Junior Reigns. Technical Breakdown of the File Name "Hawaii Five-0" He Kama Na Ka Pueo (TV Episode 2019) - IMDb

: The case ends in a standoff where Wade kills himself, and Jennifer is eventually reunited with her biological father, Daniel Nettles. Subplots and Character Details

Krasnov V.S.

Pavlov First St. Petersburg State Medical University

Kolontareva Yu.M.

Novartis Pharma LLC

Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv

Siponimod: a new view at the therapy of secondary progressive multiple sclerosis

Authors:

Krasnov V.S., Kolontareva Yu.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7): 124‑129

DOI: 10.17116/jnevro2021121071124

Read: 10020 times

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Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Table of contents
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv

SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

To cite this article:

Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
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Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
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Abstract:

Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.

Keywords:

secondary progressive multiple sclerosis
siponimod
neurodegeneration
remyelination

Authors:

Krasnov V.S.

Pavlov First St. Petersburg State Medical University Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv

Kolontareva Yu.M.

Novartis Pharma LLC

Received:

20.04.2021

Accepted:

04.06.2021

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Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv
Hawaii.Five-0.2010.S09E21.WEB.x264-TBS[eztv].mkv

: The team investigates the murder of Dale Samson, an unlicensed private investigator. The investigation reveals that Samson was searching for a girl, Jennifer Nettles, who was kidnapped 20 years prior.

: Five-0 discovers that Jennifer is living under the name Emily Henderson with her kidnapper, Wade Henderson (real name Jesse Stoltz), who raised her as his own daughter after his own family died in a car accident.

: The episode features a recurring fan-favorite element involving Ricky Schiff and a cat named Mr. Pickles , who was bequeathed to Steve, Danny, and Ricky by a deceased neighbor. The cat eventually moves into McGarrett's house, leading to a "silent standoff" with Steve’s dog, Eddie. Cast : Alex O’Loughlin as Steve McGarrett. Scott Caan as Danny "Danno" Williams. Chi McBride as Lou Grover. Jorge Garcia as Jerry Ortega. Meaghan Rath as Tani Rey. Beulah Koale as Junior Reigns. Technical Breakdown of the File Name "Hawaii Five-0" He Kama Na Ka Pueo (TV Episode 2019) - IMDb

: The case ends in a standoff where Wade kills himself, and Jennifer is eventually reunited with her biological father, Daniel Nettles. Subplots and Character Details

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