: Transmembrane segments are typically characterized by highly hydrophobic amino acid residues. HMM-TM uses these statistical properties to distinguish between membrane-spanning segments and loops.
: The software uses the Viterbi algorithm to find the most likely state path (the optimal "map") of the protein relative to the cell membrane. Alternatives for Transmembrane Prediction Download HMMATM rar
: It is compatible with TMRPres2D , a tool that generates high-resolution 2D graphical representations of the predicted protein structure. Downloading and Using the Tool Download HMMATM rar