112149 [Top 50 INSTANT]

The human TMPRSS2 (Transmembrane Protease, Serine 2) is composed of three distinct extracellular domains: SRCR Domain (Residues 150–242) Serine Protease (SP) Domain (Residues 243–492)

Efficient production of fully active, SARS-CoV-2-priming ... - PMC 112149

While the SP domain is responsible for the actual "cleaving" or priming of the viral spike protein, the serves as a vital structural anchor within the ectodomain. Understanding the specific sequence from 112 to 149 is essential for researchers attempting to produce fully active, refolded versions of the protein in laboratory settings, such as using Escherichia coli expression systems. Scientific Significance in Drug Discovery The human TMPRSS2 (Transmembrane Protease, Serine 2) is